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發(fā)布日期:2022/6/15 14:41:00

簡介:鹽酸維拉帕米, Verapamil hydrochloride是鈣離子通道 (calcium channel) 拮抗劑。

鹽酸維拉帕米物理化學(xué)性質(zhì):

密度

1.058g/cm3

沸點

586.1oC at 760 mmHg

熔點

142 °C (dec.)(lit.)

分子式

C27H39ClN2O4

分子量

491.063

閃點

308.3oC

精確質(zhì)量

490.259827

PSA

63.95

LogP

5.89508

外觀性狀

白色至灰白色粉末

儲存條件

密封于干燥陰涼處保存。

穩(wěn)定性

常溫常壓下穩(wěn)定。

禁配物: 強氧化劑

水溶解性

soluble

 

鹽酸維拉帕米詳細(xì)介紹:

中文名稱:

鹽酸維拉帕米

中文別名:

鹽酸維拉帕米;alpha-[3-[[2-(3,4-二甲氧苯基)乙基]甲氨基]丙基]-alpha-異丙基-3,4-二甲氧基苯乙腈鹽酸鹽;維拉帕米鹽酸鹽;戊脈安 鹽酸鹽;異搏定 鹽酸鹽;異搏停 鹽酸鹽;Verapamil Hydrochloride 維拉帕米鹽酸鹽;鹽酸維拉帕米 EP標(biāo)準(zhǔn)品;鹽酸維拉帕米 USP標(biāo)準(zhǔn)品;鹽酸維拉帕米 標(biāo)準(zhǔn)品;鹽酸維拉帕米、維拉帕米鹽酸鹽;鹽酸維拉帕米雜質(zhì)對照品;鹽酸鹽維拉帕米 標(biāo)準(zhǔn)品;Α-[3-[[2-(3,4-二甲氧苯基)乙基]甲氨基]丙基]-Α-異丙基-3,4-二甲氧基苯乙腈鹽酸鹽;苯噻嗪;維拉帕米,鹽酸D7;鹽酸維拉帕米,(±)-Verapamil hydrochloride;5-[(3,4-二甲氧基苯乙基)甲氨基]-2-(3,4-二甲氧基苯基)-2-異丙基戊腈鹽酸鹽;戊脈安;維拉帕米鹽酸;鹽酸維拉帕米(標(biāo)準(zhǔn)品);鹽酸維拉帕米, 一種L型鈣通道阻斷劑;鹽酸維拉帕米 戊脈安

英文名稱:

Verapamil hydrochloride

英文別名:

VERAPAMIL HYDROCHLORIDE;alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-;benzeneacetonitrile hydrochloride;5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE (+/-)-VERAPAMIL HYDROCHLORIDE;CALAN;IPROVERATRIL;ISOPTIN;(+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE;alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride;ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE;5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE;Verapamil HCl;finoptin;iproveratrilhydrochloride;izoptinhydrochloride;(±)-Verapamil hydrochloride;(+-)-VERAPAMIL HYDROCHLORIDE;(±)-Verapamil hydrochlorid;2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)-ethyl](methyl)amino]-2-isopropylpentanenitrile hydrochloride;Verapamil (hydrochloride);Verapamil Hydrochlor;Verapamil hydrochloride solution;(+/-)-Verapamil hydrochloride;(-)-VerapaMil hydrochloride;(‘±)-Verapamil hydrochloride;Verapamil hydrochloride,α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrilehydrochloride;5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride;5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2;manidon;lu20175;Rositol;cordilox;Hormitol;Magotiron;Verapamil HCI;d-365hydrochloride;verapamilchloridrate;Calcan hydrochloride;Cardibeltin;Veroptinstada;Cardioprotect;Cardiabeltin;Vetrimil;Vasopten;Vasomil;Jenapamil;Isoptino;Corpamil;Coraver;Caveril;Veratensin;Verasal;Veraloc;Veracor;Verabeta;Praecicor;Hexasoptin;Verasifar;Veramil;Ikapress;Harteze;Durasoptin;Civicor;Calaptin;Verdilac;Verapin;Verahexal;Robatelan;Lodixal;Inselon;Flamon;Elthon;Vortac;Univex;Ikacor;Rapam;Anpec;Ormil;Verapamil

CAS號:

152-11-4

分子式:

C27H39CLN2O4

分子量:

491.06

詳細(xì)描述

博飛美科商城提供的[Sigma-Aldrich](±)-Verapamil hydrochloride為博飛美科出品的其它生化試劑,產(chǎn)品穩(wěn)定,定制速度快,極大地方便了廣大科研客戶的使用需求。產(chǎn)品包裝為10G,安全運輸。

屬性:

測定:≥99% (titration)

形式:powder

顏色:white

mp:142 °C (dec.) (lit.)

溶解性:

methanol: 50 mg/mL

ethanol: soluble

SMILES string:Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI:1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H

InChI key:DOQPXTMNIUCOSY-UHFFFAOYSA-N

應(yīng)用:

鹽酸維拉帕米已被用于:

抑制受精卵中的鈣振蕩

阻斷鈣通道,從而阻斷 IL-1β(白細(xì)胞介素-1β)的作用,導(dǎo)致膜去極化

研究維拉帕米對 1,3-二亞油酰甘油(DLG)細(xì)胞毒性的影響

包裝:

1, 5, 10 g in glass bottle

生化/生理作用:

α1-腎上腺素受體拮抗劑;L型鈣通道阻滯劑。阻斷平滑肌和心肌中的 L 型 Ca2+ 通道,體外誘導(dǎo)人原發(fā)性和轉(zhuǎn)移性結(jié)腸癌細(xì)胞的凋亡。對 PGP 起作用的抗藥性逆轉(zhuǎn)劑,如減少腎小管清除地高辛。增加 Pgp 的基礎(chǔ) ATP 酶活性。Cyp3A4 和 CYP2C6 的底物。

查詢關(guān)鍵詞:152-11-4,鹽酸維拉帕米,(±)-Verapamil hydrochloride,Sigma-Aldrich,上?,F(xiàn)貨。

 

鹽酸維拉帕米參考文獻:

[1]. Meister S, et al. Calcium channel blocker Verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. Neoplasia. 2010 Jul;12(7):550-61.

[2]. Yanjiao X, et al. Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro. Drug Metab Pharmacokinet. 2013;28(6):468-74.

[3]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567.

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