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簡(jiǎn)介:布洛芬,Ibuprofen是 COX-1 和 COX-2 的抑制劑,IC50 值分別為 13 μM 和 370 μM,具有抗炎的活性。

布洛芬物理化學(xué)性質(zhì):

密度

1.0±0.1 g/cm3

沸點(diǎn)

319.6±11.0 °C at 760 mmHg

熔點(diǎn)

77-78 °C(lit.)

分子式

C13H18O2

分子量

206.281

閃點(diǎn)

216.7±14.4 °C

精確質(zhì)量

206.130676

PSA

37.3

LogP

3.72

外觀性狀

無色,結(jié)晶固體

蒸汽壓

0.0±0.7 mmHg at 25°C

折射率

1.519

儲(chǔ)存條件

常溫密閉避光,通風(fēng)干燥

穩(wěn)定性

常溫常壓下穩(wěn)定

避免的物料: 氧化物

水溶解性

insoluble

 

布洛芬詳細(xì)介紹:

中文名稱:

布洛芬

中文別名:

布洛芬;2-(4-異丁基苯基)丙酸;芬必得;異丁苯丙酸;異丁洛芬;拔怒風(fēng);對(duì)異丁苯丙酸;4-異丁基-Α-甲基苯乙酸;2-(4-異丁苯基)丙酸;2-(-4-異丁基苯基)丙酸;布洛芬 EP標(biāo)準(zhǔn)品;布洛芬 USP標(biāo)準(zhǔn)品;布洛芬 標(biāo)準(zhǔn)品;布洛芬99;布洛芬峰鑒別 EP標(biāo)準(zhǔn)品;布洛芬及雜質(zhì);布洛芬雜質(zhì);布洛芬雜質(zhì)對(duì)照品;布南色林;葡醛內(nèi)酯;羧甲司坦;紫蘇醛;2-甲基-4-(2-甲基丙基)苯乙酸;α-甲基-4-(異丁基)苯乙酸;(±)-2-(4-異丁基苯基)丙酸

英文名稱:

Ibuprofen

英文別名:

2-(4-Isobutylphenyl)propanoic acid;alpha-methyl-4-(2-methylpropyl)benzeneacetic acid;2-(4-isobutylphenyl)-propionic acid;p-isobutylhydratropic acid;RARECHEM AL BO 0989;MOTRIN(TM);(+/-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID;2-(4-ISOBUTYLPHENYL)PROPIONIC ACID;4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID;AKOS NCG1-0060;(+/-)-ALPHA-METHYL-4-(2-METHYLPROPYL)-BENZENEACETIC ACID;ALPHA-METHYL-4-[2-METHYLPROPYL]BENZENEACETIC ACID;(?à)-Ibuprofe;(±)-Ibuprofen;Ibuprofen;Ibuprofen solution;IBUPROFEN(P);rac Ibuprofen;ROSTAFUROXIN;4-Isobutyl-α-methylphenylacetic Acid;Adran;Advil;Andran;Bluton;Brufen;Dolgin;Dolgit;Fenbid;IP-82;rufen;rufin;布洛芬;Motrin;Nurofen;Nuprin;Liptan;Ibuprocin;Buburone;Medipren;Butylenin;Ibumetin;Anflagen;Lamidon;Ebufac;Mynosedin;Trendar;Roidenin;Apsifen;Haltran;Epobron;Nobfen;PediaProfen;Nobgen;Nobfelon;Suspren;Rebugen;Pantrop;Brufort;Tabalon;Inabrin;(RS)-Ibuprofen;Urem;Anco;2-[4-(2-methylpropyl)phenyl]propanoic acid;Ibu-slo;Brufanic;Ibuprohm;Napacetin;Ibufen;Ibren;4-Isobutylhydratropic acid;p-Isobutylhydratropi

CAS號(hào):

15687-27-1

分子式:

C13H18O2

分子量:

206.28

詳細(xì)描述

博飛美科商城提供的[Sigma-Aldrich]2-(4-Isobutylphenyl)propanoic Acid為博飛美科出品的其它生化試劑,產(chǎn)品穩(wěn)定,定制速度快,極大地方便了廣大科研客戶的使用需求。產(chǎn)品包裝為5G,安全運(yùn)輸。

屬性:

生物來源:synthetic (organic)

測(cè)定:≥98% (GC)

形式:powder

mp:77-78  °C

溶解性:ethanol: 50 mg/mL, clear, colorless to faintly yellow

SMILES string:CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI:1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key:HEFNNWSXXWATRW-UHFFFAOYSA-N

包裝:

1, 5, 10 g in poly bottle

生化/生理作用:

環(huán)加氧酶 (COX) 抑制劑,對(duì) COX-1 的抑制活性大于對(duì) COX-2 的抑制活性。

查詢關(guān)鍵詞:15687-27-1,布洛芬,2-(4-Isobutylphenyl)propanoic Acid,Sigma-Aldrich,上?,F(xiàn)貨。

 

布洛芬參考文獻(xiàn):

[1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

[2]. Palayoor ST, et al. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94.

[3]. Khwaja F, et al. Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res. 2004 Sep 1;64(17):6207-13.

[4]. Rao GH, et al. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. Arteriosclerosis. 1983 Jul-Aug;3(4):383-8.

[5]. Driban JB, et al. Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol. 2011;2011:691412

貨號(hào) 產(chǎn)品名稱 品牌 規(guī)格型號(hào) 包裝 目錄價(jià) 促銷價(jià) 數(shù)量 購物車
PA54587 布洛芬 ,15687-27-1 PERFEMIKER ≥98% (GC) 1kg ¥435.00
PA54587 布洛芬 ,15687-27-1 PERFEMIKER ≥98% (GC) 100g ¥80.00
PA54587 布洛芬 ,15687-27-1 PERFEMIKER ≥98% (GC) 250g ¥180.00
PA54587 布洛芬 ,15687-27-1 PERFEMIKER ≥98% (GC) 25g ¥57.00
PA54587 布洛芬 ,15687-27-1 PERFEMIKER ≥98% (GC) 5g ¥40.00
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