簡(jiǎn)介:DAPT是 γ-分泌酶 (γ-secretase) 抑制劑,抑制總 Aβ 和 Aβ42 的 IC50 分別為 115 和 200 nM。
DAPT物理化學(xué)性質(zhì):
密度 |
1.2±0.1 g/cm3 |
沸點(diǎn) |
612.2±55.0 °C at 760 mmHg |
分子式 |
C23H26F2N2O4 |
分子量 |
432.46 |
閃點(diǎn) |
324.1±31.5 °C |
精確質(zhì)量 |
432.186066 |
PSA |
84.5 |
LogP |
3.98 |
外觀性狀 |
白色固體 |
蒸汽壓 |
0.0±1.8 mmHg at 25°C |
折射率 |
1.535 |
儲(chǔ)存條件 |
2-8°C |
水溶解性 |
DMSO: ~18 mg/mL |
DAPT詳細(xì)介紹:
中文名稱: |
DAPT |
中文別名: |
DAPT (2S)-N-[N-(3,5-二氟苯乙?;?-L-丙氨酰]-2-苯基甘氨酸叔丁酯;(2S)-N-[N-(3,5-二氟苯乙?;?-L-丙氨酰]-2-苯基甘氨酸叔丁酯;(3,5-二氟苯乙?;?-L-丙氨?;?L-2-苯基甘氨酸叔丁酯;DAPT (GSI-IX) 抑制劑;N-{N-(3,5-二氟苯乙?;?-L-丙胺酰基}-S-苯甘氨酸叔丁酯;(3,5-二氟苯乙?;?-Ala-Phg-OtBu;5'-O-乙酰基利巴韋林;利巴韋林雜質(zhì)F |
英文名稱: |
Dapt |
英文別名: |
DAPT;Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-,1,1-dimethylethyl ester, (2S)-;((S)-tert-butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate);(S)-tert-Butyl 2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate;DAPT DAPT;DAPT (GSI-IX);DAPT (GSI-IX, LY-374973);N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester(DAPT);N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester;GSI IX;GSI-IX;GSI-IX LY-374973 N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester;LY-374973;DAPT (enzyme inhibitor);(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;gamma-Secretase Inhibitor IX;InSolution? gamma-Secretase Inhibitor IX;N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester;GSIIX;PubChem22 |
CAS號(hào): |
208255-80-5 |
分子式: |
C23H26F2N2O4 |
分子量: |
432.46 |
詳細(xì)描述 |
創(chuàng)賽優(yōu)選商城提供的[Sigma-Aldrich]((S)-Tert-Butyl 2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate)為創(chuàng)賽科技出品的其它生化試劑,產(chǎn)品穩(wěn)定,定制速度快,極大地方便了廣大科研客戶的使用需求。產(chǎn)品包裝為5MG,安全運(yùn)輸。 屬性: 生物來源:synthetic (organic) 質(zhì)量水平:100 測(cè)定:≥98% (HPLC) 形式:solid 顏色:white 溶解性:DMSO: ~18 mg/mL 創(chuàng)始人:Eli Lilly 儲(chǔ)存溫度:2-8°C SMILES string:C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2 InChI:1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20+/m0/s1 包裝: 5 mg in glass bottle 25 mg in poly bottle 生化/生理作用: DAPT是一種γ-分泌酶抑制劑,間接抑制Notch,即一種γ-分泌酶底物。其他的γ-分泌酶底物包括LDL受體相關(guān)蛋白、E-cadherin和ErbB-4。DAPT作為γ-分泌酶的抑制劑,在 β-淀粉樣蛋白的形成研究中可能具有重要的應(yīng)用價(jià)值。DAPT在自身免疫性和淋巴增生性疾病的研究中,如阿爾卑斯和紅斑狼瘡(SLE),以及在癌細(xì)胞生長(zhǎng)、血管生成和人類誘導(dǎo)多能干細(xì)胞(hIPSC)分化中的作用已被證明可以抑制Notch信號(hào)。 查詢關(guān)鍵詞:"208255-80-5,DAPT,GSIIX,上?,F(xiàn)貨,以Sigma官網(wǎng)為準(zhǔn)。" |
DAPT參考文獻(xiàn):
[1]. Dovey HF, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81.
[2]. Zhou JX, et al. γ-secretase inhibition combined with cisplatin enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361.
[3]. Li S, et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33(6):1257-64.
[4]. Tanimizu N, et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016 Jul;64(1):175-88.
[5]. Michael T. Chang, et al. Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma. Yale University. January 2016.
[6]. Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.
[7]. Yixin Tao, et al. β-catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis. J Mol Cell Biol. 2018 May 16.